Typically, we controlled chemistry and through it selectivity of our monolithic columns by using: (i) direct copolymerization of functional monomers, (ii) preparation of parent monolith with reactive functionalities and its post-polymerization functionalization, (iii) thermally or photoinitiated grafting of functional monomers on the pore surface, and (iv) attachment of gold and silver nanoparticles to the pore surface followed by reaction with functional thiols. Recently, a new approach was introduced that enables functionalization of pore surface of monoliths and involves application of metal-organic frameworks (MOFs). These frameworks are compounds consisting of metal ions or clusters coordinated to rigid organic molecules to form one-, two-, or three-dimensional structures that can be porous. We used two implementations: (i) admixing preformed MOF to the polymerization mixture followed by the thermally initiated free radical polymerization and (ii) forming the MOF within the pores applying layer-by-layer approach. The former technique will be demonstrated with the preparation of monolithic column designed for enantioseparation while the latter led to column for selective preconcentration of phosphopetides and to column for the separation of native fatty acids according to their length and degree of unsaturation.
Presenting author:
František Švec
The Molecular Foundry, E.O. Lawrence Berkeley National Laborator
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Authors:
Xin Wang - E.O. Lawrence Berkeley National Laboratory
Adeela Saeed - E.O. Lawrence Berkeley National Laboratory
Fernando Maya - E.O. Lawrence Berkeley National Laboratory
Alexandros Lamprou - E.O. Lawrence Berkeley National Laboratory
Hongxia Wang - E.O. Lawrence Berkeley National Laboratory
